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JBSNF-000088

Glpbio
Catalog No:GC38012-10mM (in 1mL DMSO) CAS No.:7150-23-4 MDLNo: Brand:Glpbio purity: 特性: Purpose:JBSNF-000088 (6-Methoxynicotinamide) 是烟酰胺 (NA) 的类似物,是一种有效的 NNMT (烟酰胺 N-甲基转移酶) 抑制剂,对人 NNMT,猴 NNMT 和小鼠 NNMT 的 IC50 分别为 1.8 µM,2.8 µM 和 5.0 µM。在代谢性疾病的动物模型中,JBSNF-000088 抑制 NNMT 活性,降低 MNA 水平并驱动胰岛素增敏,调节葡萄糖和减轻体重。DMSO: ≥ 100 mg/mL (657.25 mM); H2O: 1 mg/mL (6.57 mM)
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